This course introduces the evolution and academic influence of Treatise on Exogenous  Febrile Disease, the definition of exogenous febrile disease and the concept of six  meridians. It will allow the students to grasp the methods of differential diagnosis and therapeutic principles, understand the relationship between differential diagnosis in accordance with the theory of six meridians, differential diagnosis in accordance with the eight principles and differential diagnosis in accordance with the state of Zang-fu  organs, and learn the transmission of six-meridian disease.